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  • PublicationMetadata only
    Recent Developments in Chemical Synthesis and Biological Activities of Aloe-Emodin Derivatives
    (2026-04-10) Semerel, Jeltzlin; John, Nigel; Fardim, Pedro; Dehaen, Wim; Bałczewski, Piotr
    Aloe-emodin is an anthraquinone with a wide range of medicinal applications, including anti-angiogenic, anticancer, antimicrobial, antiviral, anti-inflammatory, and antioxidant activities. In this review, the functionalization of aloe-emodin using various synthetic methods, including alkylation, condensation, esterification, the Finkelstein reaction, and the Kabachnik–Fields reaction was reported. The biological activity of the synthesized aloe-emodin derivatives is discussed, with a focus on their potential future applications as anticancer agents, enzyme inhibitors, anti-inflammatory agents, and antimicrobial agents. This review also discusses the structure–activity relationship (SAR) and the mechanism of action (e.g., molecular docking studies, cell membrane-disrupting capacity, and apoptosis studies). This review highlights the many contributions made towards the design and development of novel, biologically active aloe-emodin derivatives.
  • PublicationMetadata only
    Aqueous sodium tosylate: a sustainable medium for alkylations
    (2024-02-13) Blues, Sem; Semerel, Jeltzlin; Dehaen, Wim
    Typical alkylation reactions produce significant amounts of undesired salt and solvent waste. Herein, we report an efficient alkylation protocol utilising aqueous sodium tosylate (NaTos) solutions as a hydrotrope-containing medium. The methodology represents an inexpensive and straightforward approach for preparing alkyl aryl ethers, thioethers and N-alkylated tosyl amides in high yields under mild conditions. The generated reaction waste, aqueous NaTos salt, was repurposed as a reaction medium in subsequent steps. This medium was recycled ten times without any significant change in the yield, providing an improved environmental factor over various literature examples. Under similar conditions, commonly applied solvents furnished the products with lower yields and more waste.
  • PublicationMetadata only
    Co-culture of a Novel Fermentative Bacterium, Lucifera butyrica gen. nov. sp. nov., With the Sulfur Reducer Desulfurella amilsii for Enhanced Sulfidogenesis
    (2018-12-13) Sánchez-Andrea, Irene; Florentino, Anna Patrícya; Semerel, Jeltzlin; Strepis, Nikolaos; Sousa, Diana Z.; Stams, Alfons J. M.; Mussmann, Marc
  • PublicationMetadata only
    Eutectic solvents with tuneable hydrophobicity: lipid dissolution and recovery
    (2021-02-19) Lo, Calvin; Semerel, Jeltzlin; van den Berg, Corjan; Wijffels, René H.; Eppink, Michel H. M.
    Despite the promising advantages of eutectic solvents, the application of these solvents as an extraction solvent is still limited due to the challenging product recovery. Previously, it was reported that lipids could be recovered from a hydrophobic eutectic solvent with the principle of switchable hydrophobicity. However, this method still involves additional chemicals, such as polymeric amines, water, and CO2, which need to be removed later. In this study, we proposed a different approach by shifting the hydrophobicity spectrum of a semi-hydrophobic solvent. Made of hydrophilic imidazole and hydrophobic hexanoic acid, this combination showed tuneable hydrophobicity when the composition was changed, shown by the change of dipolarity (π*) scale from solvatochromic analysis. At low imidazole content, the solvent was able to dissolve sunflower oil and algae oil, whereas, at high imidazole content, the solvent showed high affinity towards water. By adding imidazole to the solution of oil and the solvent, a phase split was induced between the oil-rich upper phase and the solvent-rich lower phase. With this approach, ∼75% of recovery efficiency was achieved for the two oils, with the purity of ∼100% for sunflower oil and 86% for algae oil.
  • PublicationOpen Access
    Van Macro naar Micro: Taal-in-Onderwijs Beleidslandschappen (Pluridentities Beleidsnota 1)
    (Pluridentities, 2026-03-25) Van Oss, Victoria; van Donselaar, Bart; Surmont, Jill; Mijts, Eric
    Deze beleidsnota vat de voorbarige resultaten samen van het Project: ‘Pluridentities: Protecting and stimulating plurilingual identities in learners in Europe via inclusive policies and classroom practices,’ gesubsidiëerd door het Horizon 2020 onderzoeks- en innovatieprogramma van de Europese Unie (No. 101178914). Het richt zich op beleidsstukken, verzameld in Aruba, België, Spanje, Zweden en Nederland als onderdeel van Werkpakket 3. Dit is een Nederlandstalige vertaling van het Engelstalige origineel.

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