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Recent Developments in Chemical Synthesis and Biological Activities of Aloe-Emodin Derivatives
Semerel, Jeltzlin
John, Nigel Fardim, Pedro Dehaen, Wim
Fardim, Pedro
Dehaen, Wim
Promotor / Advisor
Keyword
cytotoxic activity
aloe-emodin
molecular docking
anticancer
enzyme inhibitors
anti-inflammatory
antimicrobial
derivatives
structure–activity relationship
aloe-emodin
molecular docking
anticancer
enzyme inhibitors
anti-inflammatory
antimicrobial
derivatives
structure–activity relationship
Location research
Aruba
Date
2026-04-10
License
Attribution 4.0 International
Publisher
Language
en
ISSN
ISBN
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Aloe-emodin is an anthraquinone with a wide range of medicinal applications, including anti-angiogenic, anticancer, antimicrobial, antiviral, anti-inflammatory, and antioxidant activities. In this review, the functionalization of aloe-emodin using various synthetic methods, including alkylation, condensation, esterification, the Finkelstein reaction, and the Kabachnik–Fields reaction was reported. The biological activity of the synthesized aloe-emodin derivatives is discussed, with a focus on their potential future applications as anticancer agents, enzyme inhibitors, anti-inflammatory agents, and antimicrobial agents. This review also discusses the structure–activity relationship (SAR) and the mechanism of action (e.g., molecular docking studies, cell membrane-disrupting capacity, and apoptosis studies). This review highlights the many contributions made towards the design and development of novel, biologically active aloe-emodin derivatives.
Citation
Semerel, J., John, N., Fardim, P., & Dehaen, W. (2026). Recent Developments in Chemical Synthesis and Biological Activities of Aloe-Emodin Derivatives. Organics, 7(2), 16. https://doi.org/10.3390/org7020016
Sponsorship
Journal / Book / Conference
Organics